MODULATION OF CURCUMIN AND ITS DERIVATIVES AS AN ANTITUMOR AGENT

*Abeer Raslan Shaban

University Putra Malaysia

ABSTRACT

It has been proven that curcumin has an anti-tumor action against many types of cancer. The determined pathway by which curcumin acts as an antitumor agent is not fully understood. This review focuses on the pathways that could be possessed by curcumin as an antitumor agent, especially STAT-JNK, Ras/Raf/MAP kinase (ERKs JNK, and p38-MAPKs), TNF, and MMP-2,9 and how they are cross-linked. For this systemic search, we established an investigative approach to classify related literature (PRISMA framework). This approach was fitted to four databases: Scopus, Web of Sciences, Direct, and Google Scholar. The search words used are "curcumin", "Raf/MAP Kinase", "ERKs"," JNK", "P38-MAPKs", "STAT", and "MMP". All searches covered from database launch until 2021 included articles and reviews published in English only. The inclusive systematic review of this research showed that curcumin treatment affected multiple signaling pathways activated in cancer progression.

Keywords:

curcumin; STAT-JNK; Ras/Raf/MAP kinase; ERKs; TNF; MMP-2,9.

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