ASSOCIATION OF MATERNAL SERUM VITAMIN D LEVEL WITH PREECLAMPSIA

Nigar Sultana*, Md. Hasanul Haque, Tanvir Ahmed, Mohammad Kutub Uddin, Md. Mainul Islam, Zhuma Rani Paul, Maliha Parvin, Munmun Nahar Lipi and Chirangib Singha Palash

Medical Officer, Sir Salimullah Medical College Mitford Hospital, Dhaka.

ABSTRACT

Pre-eclampsia is a pregnancy specific syndrome, often resulting in several maternal and fetal morbidities. It is a disease of theories. The main causes for this disorder have not been specifically determined so far vitamin-D deficiency is proposed to be an important element in the pathogenesis of pre-eclampsia. The aim of the study is to evaluate the association of maternal serum vitamin-D level with pre-eclampsia. A case control study carried out in the department of Obstetrics and Gynecology, Institute of Child and Mother Health (ICMH), Matuail, Dhaka, from July 2018 to June 2019. A total 60 singleton pregnant women between 18-35 years of age were included in this study in their 24-40 weeks of gestation. Among them, 30 diagnosed women with pre-eclampsia as cases and the rest of the 30 matched healthy pregnant women were selected as controls their serum vitamin-D level was measured in the laboratory of the department of Biochemistry in BSMMU, Dhaka. Proteinuria was measured by the dip-stick method. Descriptive analysis was done using the analytic software SPSS V-270, were required vitamin D deficient state was more pronounced in pre-eclamptic women than the healthy controls which was 19.1310.85 and 41.1818.61 respectively considering serum vitamin-D level of 30 as a cut-off value, odd’s ratio calculation showed pre-eclampsia incidence was 8.63 times more likely in pregnant women with vitamin-D <30ng OR=8.63, CI=2.57-29.07). xss=removed r=-.460,>

Keywords:

The aim of the study is to evaluate the association of maternal serum vitamin-D level with pre-eclampsia.

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