CELLULAR SIGNALING THROUGH THE USE OF GROWTH FACTORS AND MECHANICAL STIMULUS IN NERVE REGENERATION

Ezegbe Chekwube Andrew1,4 *, Lourenco Larissa Ribeiro4, Amarachi Grace Ezegbe3* Anikwe Celestine Chidera2, Odo Kenechi Benjamin1, Ugorji Anita Chidera1, Anyoha Cross-Rapheal Chukwuebuka1, Okorafor Ezinne Chinemerem5, Juliana Marchi4

ABSTRACT

The nervous system consist of the autonomous and peripheral. Peripheral nerve injury which occurs as a result of trauma, accident and other associated factors always results in a significant loss of sensory and motor functions in an individual. The injured nerves can be successfully restored although it requires a lot of complex cellular and molecular response in order to rebuild the functional axons. When this is achieved, the damaged nerve can accurately connect with their original targets. The complete recovery of PNI has not been optimized. Exogenous growth factors (GFs) is a new and emerging therapeutic strategy that can be used in nerve regeneration. The mechanism of action of growth factor is based on the ability to activate the downstream targets of various signaling cascades via binding to the individual receptors in order to exert the multiple effect and restore the neuron and tissue regeneration. Although the GFs are associated with short half-life and rapid deactivation in body fluids. The use of nerve conduits has been able to reduce the limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.

Keywords:

Growth factors, Peripheral nerve injury, Signaling cascade, Axons

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